Gene
37/37
Cancer Type
42/42
% Germline -Pathogenic<0.50.5-11-22-55-1010-20Adrenocortical Carcinoma (41)Ampullary Carcinoma (47)Anal (48)Appendiceal Adenocarcinoma (122)Bladder (548)Bone (206)Cervical (79)Cholangiocarcinoma (288)Colorectal Adenocarcinoma (1495)Cutaneous Melanoma (322)Diffuse Glioma (836)Embryonal (112)Endometrial Carcinoma (547)Esophagogastric (429)Gastrointestinal Neuroendocrine (85)Gastrointestinal Stromal (211)Germ Cell (367)Head and Neck (279)Invasive Breast Carcinoma (2422)Lung Neuroendocrine (97)Mesothelioma (172)Nerve Sheath (33)Non Glioma CNS (71)Non-Cholangio Hepatobiliary (236)Non-Small Cell Lung (2463)Non-cutaneous Melanoma (197)Ovarian (384)Pancreatic Adenocarcinoma (758)Pancreatic Neuroendocrine (112)Prostate (1042)Renal Clear Cell Carcinoma (272)Renal Non-Clear Cell Carcinoma (190)Retinoblastoma (12)Salivary Carcinoma (149)Sex Cord Stromal (27)Skin , Non-Melanoma (196)Small Bowel (59)Small Cell Lung (132)Soft Tissue Sarcoma (666)Thymic (44)Thyroid (306)Uterine Sarcoma (127)BMPR1ARUNX1SMARCA4TMEM127TSC1SDHCKITMETSMARCB1SUFUSDHAF2SDHDDICER1STK11PTCH1PTENRETMEN1TSC2RB1CDH1FLCNSDHBVHLPMS2SDHANF1MLH1BAP1MSH6TP53PALB2MSH2FHBRCA1BRCA2APC% Loss of WT1000
37 Genes (out of 407)
Gene
Penetrance
% Germline - Pathogenic
% Loss of WT
% Somatic Driver
APC
HL
1.8
29.5
7.8
BRCA2
H
1.7
65.2
1.4
BRCA1
H
1.0
65.2
0.6
FH
HU
0.4
31.3
0.0
MSH2
H
0.2
78.9
0.6
PALB2
H
0.2
51.7
0.0
TP53
H
0.2
84.6
41.5
MSH6
H
0.2
53.6
0.8
BAP1
H
0.1
85.0
1.4
NF1
H
0.1
80.0
3.6
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