The SIGNAL resource was developed in a collaboration between the Berger and Taylor labs along with key institutional partners at Memorial Sloan Kettering with the goal of establishing a resource of integrated germline and somatic alterations identified by clinical sequencing of active cancer patients. Provided here are pathogenic germline variants and their tumor-specific zygosity changes by gene, lineage, and cancer type in 17,152 prospectively sequenced cancer patients. All analyses are described in:

• Srinivasan, P., Bandlamudi, C., Jonsson, P. et al. The context-specific role of germline pathogenicity in tumorigenesis. Nat Genet 53, 1577–1585 (2021).

Incremental updates based on increasingly larger cohort analysis will be provided at regular intervals.

Contributors

Members of the Berger and Taylor labs along with members of Computational Sciences in the Kravis Center for Molecular Oncology, Clinical Bioinformatics in Diagnostic Molecular Pathology, and the Niehaus Center for Inherited Cancer Genomics.